• The functional specificity of ECs forming the microcirculati

  2018-10-24

  

  The functional specificity of ECs forming the microcirculation of organs has long been appreciated and recently defined molecularly by Nolan et al. (2013). The characterization of the KDR+ endoderm cell-derived ECs generated in mouse and hESC cultures suggests that those are the specialized sinusoid

• Although previous studies begin to recognize the potential c

  2018-10-24

  

  Although previous studies begin to recognize the potential complex genetic architecture of leukemia, unambiguous longitudinal detection of leukemic clones remains difficult to achieve. Ideally, clones should be prospectively defined by unique labeling of mk-801 before tumor initiation, and detectio

• Owing to the colocalization between mitochondria and the

  2018-10-24

  

  Owing to the colocalization between mitochondria and the germ plasm of some animals, models whereby the Balbiani body selects the healthiest mitochondria for the next generation have been proposed (Cox and Spradling, 2003; Pepling and Spradling, 1998). Early as well as more recent studies thus exami

• Herein we describe increased VEGFA and SEMA

  2018-10-24

  

  Herein, we describe increased VEGFA and SEMA3A expression in bone marrow 5z from de novo AML patients and the possible dominant effect of SEMA3A, suggesting that SEMA3A could control the effects caused by VEGFA. However, some questions remain: Why is SEMA3A expression increased in BMSCs from MDS and

• In previous tumor studies we have

  2018-10-24

  

  In previous tumor studies, we have used a p53-null syngeneic mouse model to mimic p53 loss of function in human breast cancer. This model was developed by transplanting p53-null mammary epithelium into the cleared mammary fat pads of wild-type, syngeneic Balb/c-recipient mice, resulting in spontaneo

• br Experimental Procedures br Acknowledgments

  2018-10-24

  

  Experimental Procedures Acknowledgments Introduction Hematopoietic stem notch pathway (HSCs) are capable of both self-renewal and production of mature blood lineages. Players in this balanced regulation include transcription factors, cell-cycle regulators, signaling molecules, surface recep

• AEG 3482 manufacturer Rejection might also have occurred as

  2018-10-24

  

  Rejection might also have occurred as iPSC-CMs might fail to suppress recipient NK AEG 3482 manufacturer in MHC-matched transplantation. MHC class I molecules such as MHC-E, which are expressed on almost all cells in the body, bind to receptors on NK cells to inhibit cytotoxic activity and, followin

• br Experimental Procedures br Author

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We thank the members of the Department of Stem Cells and Developmental Biology for their discussions. We are grateful to Najmeh Sadat Masoudi for karyotyping, Fazel Samani for assistance with flow cytometry, and Mostafa Najar-Asl

• This has important implications for

  2018-10-24

  

  This has important implications for competitive transplantation experiments. Because they have the same reconstitution potential, modified HSPCs from any C57BL/6N or C57BL/6J strain can be directed compared with our CD45.1STEM strain without an additional control group. This contrasts with the situa

• The Mx Cre system can be potentially

  2018-10-24

  

  The Mx1-Cre system can be potentially associated with additional problems. For instance, pIpC administration has been suggested to trigger HSC cycling, similar to interferon itself (Essers et al., 2009; Gidali et al., 1981; Sugiyama et al., 2006). While we found less evidence for a dramatic effect o

• By IF we detected an overall increase in tau

  2018-10-24

  

  By IF we detected an overall increase in tau in A152T neurons, with particular accumulation of P-tau in the cell body, consistent with somatodendritic redistribution of tau, as described for tauopathies and Alzheimer’s disease (de Calignon et al., 2012; Fong et al., 2013; Li et al., 2011; Sydow et a

• br Results br Discussion In this study we

  2018-10-24

  

  Results Discussion In this study we present evidence and show that hPSCs mostly adopt a rostral-dorsal identity during in vitro neural differentiation with both EB and AD paradigms in the absence of patterning morphogens. SHH patterns in vitro differentiated human neuroectoderm under both EB a

• br Experimental Procedures br Author Contributions

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We wish to thank the cytometer unit of CABIMER for technical support, Diana Aguilar for critical reading of the manuscript, and Veronica Raker for style corrections. This work was funded by an R + D + I grant from the Spanish Mini

• These data provide a physiological explanation

  2018-10-24

  

  These data provide a physiological explanation as to the mechanism governing the robust ROS generated and non-apoptotic death observed when tp53 is functionally mutated. That is, the mitochondria of tp53 mutants are undergoing OXPHOS at an elevated rate, and therefore lack significant reserve to han

• The stationary solution of the system of equations

  2018-10-24

  

  The stationary solution of the system of equations (1) has the form: where Since the intermode interval Δ0 = 0.05, for calculation convenience, similarly to the supposition made in [6], let us assume that the axial mode of the resonator corresponding to the maximum gain at the 1064.15 nm wavelen

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