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br Methods The Spanish GEM MAS trial lasted from
2019-06-13
Methods The Spanish GEM05MAS65 trial lasted from March, 2006 to October, 2008 and included 260 patients from 63 Spanish centers. At study entry, every patient was aged 65 years or older and had newly diagnosed, untreated, symptomatic, measurable MM. These patients had received a homogeneous induc
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In the past two decades several
2019-06-13
In the past two decades, several studies have consistently found that up to one-sixth of cancers worldwide are attributable to infectious pathogens. Cancers caused by infectious agents present unique opportunities for prevention and treatment; therefore, a detailed understanding of how infections co
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Delays in diagnosis due to
2019-06-12
Delays in diagnosis due to the subtlety and focal nature of the intravascular infiltrates often lead to a terminal disease with death before chemotherapy is initiated. R-CHOP plus CNS prophylaxis is the treatment of choice in patients [30,31] without Ro 31-8220 methanesulfonate manufacturer involve
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br We have reviewed the issues and arguments
2019-06-12
We have reviewed the issues and arguments presented by Wang et al. In fact, we have well-clarified these issues in “Discussion” section of our original article. The aim of our study was to investigate the expression of maternal antineuronal diltiazem hcl and their role in childhood autism spectr
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br Conflict of interest br Introduction
2019-06-12
Conflict of interest Introduction Idiopathic left ventricular tachycardia (ILVT) with a right bundle-branch block (RBBB) configuration and superior or left axis is a distinct entity that arises in the left ventricle, mostly because of a reentry mechanism and is usually verapamil sensitive [1–6
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Roux en Y gastric bypass
2019-06-12
Roux-en-Y gastric bypass surgery is a common cause of malabsorption associated with hyperoxaluria in obese patients and those with malignancies. Postoperatively, patients may have steatorrhea, weight loss, and diarrhea, resulting in malabsorption syndrome, which would increase excessive intraluminal
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The canonical or catenin dependent Wnt signaling pathway
2019-06-12
The canonical, or β-catenin dependent, Wnt signaling pathway is critical for the regulation of osteoblast proliferation and survival [95]. Soluble inhibitors of the canonical Wnt pathway such as Dickkopf (DKK1), produced by OBL, and sclerostin, from osteocytes, play important roles in the regulation
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The re treatment of metastatic
2019-06-12
The re-treatment of metastatic bone disease causing recurrent pain after an initial course of EBRT was seen to be feasible with a reasonable rate of symptom relief [13–19]. In echoing the ACR findings, the task force noted that the available data was derived from studies where re-treatment was not t
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A previous study from our group demonstrated that the
2019-06-12
A previous study from our group demonstrated that the truncated form of OPG (1-194) has greater activity than the complete form, given that proteoglycans present in the bone tumor microenvironment may bind to full length OPG, thereby limiting its bioavailability and bioactivity [31]. Therefore the t
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Given the recognized effects of bisphosphonates in
2019-06-12
Given the recognized effects of bisphosphonates in metastatic breast cancer [14,15] and that potential anticancer effects have been demonstrated in preclinical [16], translational [17], patients with cancer therapy-induced bone loss [18] and 1-Deoxynojirimycin based-studies [19,20] a number of clin
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There is strong agreement that
2019-06-12
There is strong agreement that HIV prevention should focus on approaches that are evidence based, but there is disagreement about how to obtain such rigorous evidence and whether this should refer only to randomised study designs. Pickles and colleagues\' report provides a concrete example of an eff
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Performance based financing often highlighted in Rwanda s st
2019-06-12
Performance-based financing, often highlighted in Rwanda\'s story, has had mixed results when applied elsewhere, partly because of breakdowns in execution. For example, the failure of the performance-based financing initiative in neighbouring Uganda was caused by challenges in setting targets, deliv
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br Imagine providing care for low birthweight LBW lighter th
2019-06-12
Imagine providing care for 900 000 low birthweight (LBW; lighter than 2500 g) newborn babies each year in sub-Saharan Africa—all attributable to preventable and treatable malaria. Many of these LBW babies will be born in rural and impoverished settings where access to health care is poorest and th
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Seg n el coeficiente de Gini que
2019-06-12
Según el coeficiente de Gini que mide la desigualdad, en la región es de 0.51, nivel de desigualdad sustancialmente más alto que otras zonas del mundo, al tener en cuenta que Estados Unidos tiene 0.378 y los países de la ocde 0.313. De ahí que el promedio simple de los valores en América Latina indi
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Obesity with excessive fat was an important risk
2019-06-11
Obesity with excessive fat was an important risk factor for the occurrence or progression of cardiac arrhythmia. As compared to abdominal fat, the amount of epicardial fat more correlates with the occurrences of atrial fibrillation, which suggests the distinctive arrhythmogenic effects of epicardial
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