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Roux en Y gastric bypass
2019-06-12
Roux-en-Y gastric bypass surgery is a common cause of malabsorption associated with hyperoxaluria in obese patients and those with malignancies. Postoperatively, patients may have steatorrhea, weight loss, and diarrhea, resulting in malabsorption syndrome, which would increase excessive intraluminal
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The canonical or catenin dependent Wnt signaling pathway
2019-06-12
The canonical, or β-catenin dependent, Wnt signaling pathway is critical for the regulation of osteoblast proliferation and survival [95]. Soluble inhibitors of the canonical Wnt pathway such as Dickkopf (DKK1), produced by OBL, and sclerostin, from osteocytes, play important roles in the regulation
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The re treatment of metastatic
2019-06-12
The re-treatment of metastatic bone disease causing recurrent pain after an initial course of EBRT was seen to be feasible with a reasonable rate of symptom relief [13–19]. In echoing the ACR findings, the task force noted that the available data was derived from studies where re-treatment was not t
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A previous study from our group demonstrated that the
2019-06-12
A previous study from our group demonstrated that the truncated form of OPG (1-194) has greater activity than the complete form, given that proteoglycans present in the bone tumor microenvironment may bind to full length OPG, thereby limiting its bioavailability and bioactivity [31]. Therefore the t
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Given the recognized effects of bisphosphonates in
2019-06-12
Given the recognized effects of bisphosphonates in metastatic breast cancer [14,15] and that potential anticancer effects have been demonstrated in preclinical [16], translational [17], patients with cancer therapy-induced bone loss [18] and 1-Deoxynojirimycin based-studies [19,20] a number of clin
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There is strong agreement that
2019-06-12
There is strong agreement that HIV prevention should focus on approaches that are evidence based, but there is disagreement about how to obtain such rigorous evidence and whether this should refer only to randomised study designs. Pickles and colleagues\' report provides a concrete example of an eff
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Performance based financing often highlighted in Rwanda s st
2019-06-12
Performance-based financing, often highlighted in Rwanda\'s story, has had mixed results when applied elsewhere, partly because of breakdowns in execution. For example, the failure of the performance-based financing initiative in neighbouring Uganda was caused by challenges in setting targets, deliv
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br Imagine providing care for low birthweight LBW lighter th
2019-06-12
Imagine providing care for 900 000 low birthweight (LBW; lighter than 2500 g) newborn babies each year in sub-Saharan Africa—all attributable to preventable and treatable malaria. Many of these LBW babies will be born in rural and impoverished settings where access to health care is poorest and th
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Seg n el coeficiente de Gini que
2019-06-12
Según el coeficiente de Gini que mide la desigualdad, en la región es de 0.51, nivel de desigualdad sustancialmente más alto que otras zonas del mundo, al tener en cuenta que Estados Unidos tiene 0.378 y los países de la ocde 0.313. De ahí que el promedio simple de los valores en América Latina indi
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Obesity with excessive fat was an important risk
2019-06-11
Obesity with excessive fat was an important risk factor for the occurrence or progression of cardiac arrhythmia. As compared to abdominal fat, the amount of epicardial fat more correlates with the occurrences of atrial fibrillation, which suggests the distinctive arrhythmogenic effects of epicardial
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Igualmente podr a ampliarse su cr tica a la
2019-06-11
Igualmente, podría ampliarse su crítica O4I1 la modernidad occidental, entendida como proyecto civilizatorio orientado por la totalización de la racionalidad instrumental y el mito del progreso. La modernidad occidental no es sólo expresión de una racionalidad fetichizada. En tanto capitalismo globa
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br ECM cancer and metastasis
2019-06-11
ECM, cancer and metastasis For serine protease inhibitors to become cancerous they must acquire the ability to survive, grow and invade leading to malignant transformation, tumour formation and ultimately overt secondary metastasis. Abnormal ECM can promote these abilities and is a well-documente
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Introduction Atrial fibrillation AF is the most common cardi
2019-06-11
Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia, and it commonly occurs after cardiac surgery. AF is often associated with stroke, congestive heart failure, and myocardial infarction, all of which contribute to the increase in the length of hospital stay, higher medical
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In Richard Walker and colleagues report the results
2019-06-11
In , Richard Walker and colleagues report the results of a case-control study of risk factors for stroke in Tanzania. Their study makes several important contributions. First, they provide the first information about importance of risk factors for stroke in urban and rural Tanzania, and confirm the
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br The introduction of direct acting
2019-06-11
The introduction of direct-acting antiviral drugs (DAAs) is changing the treatment options for hepatitis C calculating dilutions (HCV). These new medicines were initially marketed at a very high price, but several countries have negotiated favourable price reductions, and, in view of the low cost
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