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Boyle et al compared the effects
2020-08-05
Boyle et al. [1] compared the effects of dextrose, diazoxide, and octreotide on hypoglycemia induced by glipizide overdose (1.45mg/kg: 20 times the recommended starting dose) in non-diabetic subjects. In the subjects treated with dextrose alone, IRI levels were elevated to 240pmol/L. In our patient,
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The focus of this work was to
2020-08-05
The focus of this work was to determine which E. coli genes contribute to survival upon exposure to CAA and SO. We first analyzed the expression of certain stress response genes upon exposure to each agent, using the established Transcriptional Effect Level Index (TELI) assay [34]. The main advantag
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In conclusion MEN behave as
2020-08-05
In conclusion, MEN91507 behave as a potent and selective CysLT1antagonist in guinea-pigs and human in vitro assays. In vivo, MEN91507 shares with the other CysLT1 antagonists anti-bronchospastic and anti-inflammatory effects; since these effects are long-lasting and are also observed following the o
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The CYP A structure manifest larger active site
2020-08-05
The CYP3A4 structure manifest larger active site and a closely existing large solvent channel to facilitate oxidation of larger or multiple substrate. This solvent channel is formed by interaction among tyrosine (Y-53), aspartic glasdegib (D-61), aspartic acid (D-76), arginine (R-106), arginine (R-
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br Materials and methods br Results br
2020-08-05
Materials and methods Results Discussion Emerging evidence suggests that mAchR and ligands participate in regulating cellular proliferation and cancer progression, in particular in colon cancer (for review [48]). These effects have been sometimes attributed to mAchR-induced transactivation
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Given innate differences in PFC DA tone between P and
2020-08-05
Given innate differences in PFC DA tone between P and Wistar rats (Engleman et al., 2006), coupled with our findings that COMT expression differs by strain and sex in the PFC, we hypothesize that tolcapone exerts its effects primarily on cortical catecholamines. However, high COMT expression in the
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In the frontal cortex the present study found a
2020-08-05
In the frontal cortex, the present study found a relationship between working memory performance and activated Erk2 expression for the E2-only group, where animals that tended to perform better on the WMC measure tended to have higher activated Erk2 expression. This suggests that there is a unique r
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In conclusion both pathways are interesting potential
2020-08-05
In conclusion, both pathways are interesting potential targets for ES as they either hypothetically interact with the EWSR1-FLI1 or EWSR1-ERG fusion product and/or show promising (pre)clinical data. Therapeutic strategies should therefore definitely be explored further, and we will need to better un
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br Experimental Procedures br Author Contributions M
2020-08-04
Experimental Procedures Author Contributions M.B., with input and help from T.T.H., conceived the project, designed and performed the experiments, analyzed the data, and wrote the manuscript. B.B.B. and F.D.M. synthesized the wild-type and (nonhydrolyzable, NH) Ub tetramers and contributed Fig
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Traditionally serum triglycerides have been
2020-08-04
Traditionally, serum triglycerides have been measured in the clinic in the fasted state in order to reduce variability and also to facilitate the calculation of LDL-cholesterol via the Friedewald equation, which was derived using fasted samples (Warnick and Nakajima, 2008). We have previously report
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br Development and germination of
2020-08-04
Development and germination of cereal seeds Caryopses (cereal grains) are the propagation units of many monocot species, such as wheat, triticale, barley and other cereal species. A caryopsis is a type of dry fruit composed of three tissues: the diploid embryo, the triploid endosperm and the mate
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br Conclusion br Conflicts of interest br Acknowledgements T
2020-08-04
Conclusion Conflicts of interest Acknowledgements This study was financially supported by The Science and Engineering Research Board (SERB), Department of Science & Technology (DST), Government of India under the Fast Track Scheme for Young Scientist to Dr. V. Dhananjayan (No: SB/FT/LS-140/
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br Conclusion The results presented herein indicate that lar
2020-08-04
Conclusion The results presented herein indicate that large peptides were generated earlier than small sequences during GE hydrolysis of α-caseins. Furthermore, incubation temperature had an important effect in promoting the hydrolysis. The time for the iTRAQ-labelling process needs to be optimis
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mAbs directed against RTKs are invaluable tools
2020-08-04
mAbs directed against RTKs are invaluable tools for research and have been developed into successful therapeutics (Adams and Weiner, 2005). We have characterized seven anti-DDR1 mAbs that inhibit DDR1 function by binding to two distinct regions in the DS-like domain. Notably, Fab fragments derived f
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br Materials and methods br Results
2020-08-04
Materials and methods Results We have previously demonstrated that 4 days of retinol pretreatment (75 mg/kg/day) potentiates paracetamol-induced hepatotoxicity in the male Swiss Webster mouse (Rosengren et al., 1995). We have replicated this finding in another strain, the BALB/c mouse (Fig. 1)
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