• Introduction Post pneumonectomy lung growth is a

  2018-10-22

  

  Introduction Post-pneumonectomy lung growth is a striking example of adult tissue morphogenesis. In many mammalian species, including humans (Butler et al., 2012; Kajstura et al., 2011), removal of one lung is associated with compensatory growth of the remaining lung to near-baseline levels (Hsia e

• In relation to SSEA expression the differentiation

  2018-10-22

  

  In relation to SSEA3 expression, the ‘differentiation threshold’ may lie at different points along the linear path of differentiation (Fig. 4) depending on the cell line and the culture conditions used to propagate undifferentiated ES cells. In comparison to normal human ES cells, the adapted human

• br Acknowledgments br Introduction Mouse embryonic stem ES c

  2018-10-22

  

  Acknowledgments Introduction Mouse embryonic stem (ES) UMI-77 can give rise to all somatic cell types and germ cells in a regulative manner and are thereby defined as pluripotent. They are thought to have ‘no pre-determined programme’. However, whether or not an ES cell represents a ‘tabula r

• We have utilized an adenovirus Ad vector

  2018-10-22

  

  We have utilized an adenovirus (Ad) vector as a tool for transduction of functional genes into stem cells, because Ad vectors are relatively easy to construct, can be produced at high titers, and mediate efficient and transient gene expression in both dividing and nondividing cells. We have demonstr

• The differential findings between eltrombopag and TPO sugges

  2018-10-22

  

  The differential findings between eltrombopag and TPO suggested the possibility that separate intracellular signaling pathways might have taken place in mediating proliferation vs. differentiation of HSC/HPCs mediated by c-Mpl. To look for the potential mechanisms behind the functional difference be

• Understanding the means by which the diverse pathways

  2018-10-22

  

  Understanding the means by which the diverse pathways governing hESC fate can be modulated by extrinsic factors and the relative importance of other signal transduction pathways to mediate these effects is of importance for the development of safe and efficacious culture systems. A fundamental start

• Interestingly our data showed that

  2018-10-22

  

  Interestingly, our data showed that when eLSKSLAM were co-cultured with individual ploidy MM, the significant increase in proliferation was no longer observed. In addition, we observed less than expected proliferation when eLSKSLAM Cyanine3.5 carboxylic acid cost were co-cultured with MM that had be

• Having confirmed that the Nanog iPSCs expressed key markers

  2018-10-22

  

  Having confirmed that the Nanog−/− iPSCs expressed key markers of pluripotency, we sought to determine the extent to which the global expression profile of Nanog−/− iPSCs recapitulated that of ESCs. To this end, we performed RNA sequencing (RNA-seq) of two replicates each of control Nanog+/+ ESC, iP

• Current hypotheses for this source draw on

  2018-10-22

  

  Current hypotheses for this source draw on diverse observations. Paneth MK2 inhibitor are a favored epithelial source because they reside in intimate contact with Lgr5+ ISCs (Barker et al., 2007; Cheng and Leblond, 1974) and their coculture with the latter improves intestinal organoid formation (Sat

• Although our report mainly focuses

  2018-10-22

  

  Although our report mainly focuses on the generation of clinical-grade hESCs, transplantation safety is also a concern. For example, a 9-year-old boy was diagnosed with a glioneuronal neoplasm after being transplanted with neural stem daminozide derived from two donors (Amariglio et al., 2009). Alth

• The optimized encapsulation protocol from above allows for s

  2018-10-22

  

  The optimized encapsulation protocol from above allows for single hESC to survive, proliferate and form dihydrofolate reductase inhibitor within the microcapsules in the presence of RI. The chemical compound has been shown to inhibit cell apoptosis, resulting in >80±5% hESC viability inside a capsul

• br Conclusions A simplified schematic

  2018-10-20

  

  Conclusions A simplified schematic model is proposed (see Fig. 7) illustrating how Lox and Twist are involved in the BMP4-induced EMT-like response and adipocyte lineage commitment. In brief, BMP4 results in increased expression of Lox (Huang et al., 2009) and Twist thus promotes the EMT-like res

• This work was supported by the

  2018-10-20

  

  This work was supported by the Elsa U. Pardee Foundation research grant, an American Heart Association grant #0765185B, the Wayne State University Cardiovascular Research Institute Isis Initiative award, and American Cancer Society Institutional Research Grant #11-053-01-IRG (to C.L.), and the Leuke

• The presence of major differences among fibroblasts isolated

  2018-10-20

  

  The presence of major differences among fibroblasts isolated from various organs and tissues have been described several decades ago. Castor et al have described striking differences between fibroblasts from skin, periosteum, pericarpdium and synovial tissue in terms of proliferative potential, buy

• These differentiated HLCs retain a strong fetal and immature

  2018-10-20

  

  These differentiated HLCs retain a strong fetal and immature phenotype, as demonstrated by the persistence of alpha-fetoprotein (AFP) and diminished hepatic functions when compared to primary adult hepatocytes (PHHs). Strategies to improve the differentiation protocol are being explored. For example

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