• Transduction of cellular signals by G protein

  2019-07-02

  

  Transduction of cellular signals by G protein-coupled receptors (GPCRs) is stringently regulated to prevent the deleterious effects of unrestrained GPCR signaling. The rapid termination of signaling mediated by agonist-occupied GPCRs is referred to as homologous desensitization and involves the foll

• Introduction Hematopoietic stem cells HSCs in the adult bone

  2019-07-02

  

  Introduction Hematopoietic stem cantharidin what (HSCs) in the adult bone marrow (BM) provide all types of blood cells throughout life, while also self-renewing to maintain blood homeostasis. Blood/marrow stem cell transplantation is the most advanced method to cure patients suffering from hematol

• Epac proteins consist of a

  2019-07-02

  

  Epac proteins consist of a carboxyl-terminal catalytic region and an amino-terminal regulatory region, which harbors one cAMP-binding domain in Epac1 and two in Epac2 [22], [32], [51]. In the absence of cAMP, the regulatory region covers the CDC25-homology domain and autoinhibits Epac\'s enzymatic a

• Interest in the PGE EP pathway is

  2019-07-02

  

  Interest in the PGE2/EP4 pathway is increasing given its diverse capability of regulating central nervous system activity [13]. EP4 has a protective function by reducing cerebral injury and improving functional outcome after stroke [14], and in suppressing o-Phenanthroline weight inflammation [15].

• The compounds listed in Table

  2019-07-02

  

  The compounds listed in Table 1, Table 2, Table 3, Table 4, Table 5 were biologically evaluated for their inhibition of the specific binding of a radiolabeled ligand [3H]PGE2 to membrane fractions prepared from cells stably expressing each mouse prostanoid receptor. The EP1 antagonist activity of th

• Doxorubicin Accordingly we prepared three compounds and as

  2019-07-02

  

  Accordingly, we prepared three compounds (, , and ) as shown in . Condensation of commercially available Doxorubicin with glycine methyl ester gave amide . A Friedel–Crafts reaction between compound and 4-methyl valeryl chloride in the presence of aluminum chloride mainly produced undesired comp

• These studies established IAP proteins as dimeric

  2019-07-02

  

  These studies established IAP proteins as dimeric RING E3 ligases, but did not account for the essential role of dimerization. In IAPs and related E3s, such as RNF4 and MDM2, dimerization not only depends on contacts from the core RING domain but also residues N- and C-terminal to the RING domain (B

• Fer-1 br Conflicts of interest br Financial support NZ is an

  2019-07-02

  

  Conflicts of interest Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818

• CDK S phosphorylation status influences the

  2019-07-01

  

  CDK5-S47 phosphorylation status influences the differential cellular proliferation versus migration response: Previous work from our laboratory has shown CDK5 to be a critical determinant of the cellular proliferation-migration dichotomy whereby CDK5 activation downstream of stimulated epidermal gro

• Chk and Chk are functionally redundant

  2019-07-01

  

  Chk1 and Chk2 are functionally redundant protein kinases that respond to checkpoint signals emanating from the phosphatidylinositol 3-kinase family members ATM (ataxia-telangiectasia mutated) and ATR (Ataxia-telangiectasia and Rad-3 related). A concerted research effort has revealed many mechanistic

• br Material and methods br

  2019-07-01

  

  Material and methods Results Discussion The present study provides clinical, molecular, and in vitro electro-physiological evidence that a rare SNP (KCNE1-D85N) can act as a genetic modifier in LQTS. In general, SNPs are thought to be non-pathological, but some have been reported to modify

• cisapride structure br The follow up clinic These trial resu

  2019-07-01

  

  The follow-up clinic These trial results have significant implications for clinic efficiencies. The safe and effective replacement of the bulk of “routine” in-clinic evaluations demonstrated in TRUST (Fig. 3) has a huge implication for resource utilization. Although demanding adjustment to differ

• br Case report A year old man

  2019-07-01

  

  Case report A 54-year-old man with a surgically repaired DORV was admitted to our hospital due to palpitations and worsened right ventricular heart failure. He had been diagnosed with DORV and had undergone the Blalock Taussig operation at 7 years of age. He underwent the Rastelli operation at 35

• In Tara Mangal and colleagues report the results of

  2019-07-01

  

  In , Tara Mangal and colleagues report the results of their case-control study into the persistence of poliomyelitis in Nigeria, which identified low vaccine efficacy, poor vaccine coverage, suboptimum Sweroside immunity, rejection and refusal of vaccine, and lack of awareness as issues responsible

• Economic sanctions have exacerbated the brutality of this

  2019-07-01

  

  Economic sanctions have exacerbated the brutality of this conflict many-fold, removing any prospects for peace and reconciliation. We need some reality to gauge their manifold effects before Syria descends into another Iraq, the devastating health consequences of which were well documented. Syria u

14596 records 912/974 page Previous Next First page 上5页 911912913914915 下5页 Last page