• Sexual size dimorphism has been

  2022-02-23

  

  Sexual size dimorphism has been observed in European eel and half-smooth tongue sole (Cynoglossus semilaevis), as females have a faster growth rate than males, (Degani, G., et al., 2003, Ma, Q., et al., 2012). Ma et al. 2011 reported that the mRNA level of GH was higher in the pituitary gland of bot

• In order to test the influence of the initial depolarization

  2022-02-23

  

  In order to test the influence of the initial depolarization, experiments were performed, where the degree of chloride substitution was varied, either by adding n-Ringer to pgp inhibitors incubated in a sucrose Ringer or by suspending the cells directly in Ringers identical to the final composition

• br Conclusion br Acknowledgements br Introduction Aminobutyr

  2022-02-23

  

  Conclusion Acknowledgements Introduction γ- Aminobutyric Adaptaquin (GABA) is the main inhibitory neurotransmitter in the adult central nervous system. GABA receptors are divided into two classes, GABAA and GABAB. GABAA is an ionotropic receptor that mediates fast GABA responses by opening

• In contrast with the above

  2022-02-23

  

  In Aripiprazole with the above results, in our GC model system, FPR1-, but not FPR2-knockout, enhanced tumour formation. However, it should be noted that the prominent role of mFPR2 with respect to mFPR1 in the mouse colon might be due to the significantly higher expression of mFPR2 than mFPR1 in th

• This study introduces a mouse model carrying the

  2022-02-23

  

  This study introduces a mouse model carrying the point mutation R258W in Ffar1, which abolishes the stimulation of insulin secretion in response to long chain fatty acids. The minimal genetic alteration mirrors the human situation and has the advantage over conventional knockout/congenic mouse model

• While earlier reports on ferroptosis

  2022-02-23

  

  While earlier reports on ferroptosis did not clarify mitochondrial damage and consequent death signaling in this paradigm of oxidative death, evidence from recent studies in neuronal systems strongly suggested a mechanistic link between enhanced lipid peroxide formation and loss of mitochondrial int

• The exocytosis promotion is triggered upon the

  2022-02-23

  

  The 2-Chlorotrityl Chloride Resin promotion is triggered upon the binding of Ca2+ to the C2 domains of two key protein groups, i.e. complexin and certain synaptogamins (Lai et al., 2017; Rizo and Xu, 2015). The first step of the vesicle fusion is the priming of the secretory vesicles, involved at t

• Acknowledgments The authors would like to thank

  2022-02-23

  

  Acknowledgments The authors would like to thank members of the Department of Discovery Synthesis (DDS) and Biocon-Bristol Myers Squibb Research Center (BBRC) for scaling up key intermediates, analytical team for analytical experiments, lead profiling group for evaluating compounds in an in vitro AD

• Maillard reaction also known as non enzymatic browning react

  2022-02-23

  

  Maillard reaction, also known as non-enzymatic browning reaction, is a complex chemical reaction between carbonyl groups of reducing sugars and free amino groups of amino acids, peptides, proteins or some other nitrogen containing compounds. Maillard reaction plays an important role in food industry

• Mevastatin synthesis br Author Contributions br Acknowledgme

  2022-02-22

  

  Author Contributions Acknowledgments We thank Hiroyuki Miyoshi, Makoto Nakanishi, Yoshikazu Johmura, Yuki Okada, Yoshinori Makino, Takashi Sutani, and Katsuhiko Shirahige for kindly providing materials and technical information, Shiho Takahashi-Kariyazono for technical advice, and all members

• Whilst it has long been appreciated that Rho family GTPases

  2022-02-22

  

  Whilst it has long been appreciated that Rho-family GTPases are able to signal directly to focal adhesions, it is also becoming increasingly clear that they can achieve this indirectly, through their influence on the extracellular matrix to which the integrins bind. Cdc42 and RhoA have long been kno

• The frequency of GSTM and GSTT null genotypes vary in

  2022-02-22

  

  The frequency of GSTM1 and GSTT1 null genotypes vary in different populations. For example, Hiragi et al. (2007) reported a frequency of 17–35% for the GSTM1 null genotype and 22–44% for the GSTT1 null genotype in Brazilians of African descent (Hiragi et al., 2007). Chen, Liu, and Relling (1996) rep

• The experiments reported herein were designed

  2022-02-22

  

  The experiments reported herein were designed to test whether co-expression of MRP and GSTP1-1 offers a level of protection from certain cytotoxic drugs not achieved by the expression of either protein alone. This was accomplished by stable transfection with expression vectors into MCF7/WT cells, w

• To date no studies have demonstrated any

  2022-02-22

  

  To date, no studies have demonstrated any effect of obesity or inflammation on GPR109A expression in adipose tissue. Our findings demonstrate that HFD-induced obesity decreases adipose tissue GPR109A gene expression. Contradictory to our findings in adipose tissue in vivo, Digby et al. report that e

• A subsequent modeling study by a different group was based

  2022-02-22

  

  A subsequent modeling study by a different group was based on the bovine rhodopsin homology model using the 1L9H construct [38]. However, the site-directed mutagenesis data and docking suggested that the niacin-binding pocket is different to that described in the aforementioned report, but similar t

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